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1

Towards a widespread adoption of metabolic modeling tools in biopharmaceutical industry: a process systems biology engineering perspective

Richelle, Anne, David, Blandine, Demaegd, Didier, Dewerchin, Marianne, Kinet, Romain, Morreale, Angelo, Portela, Rui, Zune, Quentin, von Stosch, Moritz

Journal:

npj Systems Biology and Applications

Year:

2020

Language:

english

File:

PDF, 586 KB

english, 2020

2

A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis

De Gendt, K., Swinnen, J. V., Saunders, P. T. K., Schoonjans, L., Dewerchin, M., Devos, A., Tan, K., Atanassova, N., Claessens, F., Lecureuil, C., Heyns, W., Carmeliet, P., Guillou, F., Sharpe, R. M.,

Journal:

Proceedings of the National Academy of Sciences

Year:

2004

Language:

english

File:

PDF, 459 KB

english, 2004

3

Generation of Pex5-loxP mice allowing the conditional elimination of peroxisomes

M. Baes, M. Dewerchin, A. Janssen, D. Collen, P. Carmeliet

Journal:

Year:

2002

Language:

english

File:

PDF, 190 KB

english, 2002

4

Endogenous α2-antiplasmin does not enhance glomerular fibrin deposition or injury in glomerulonephritis

A. R. Kitching, A. L. Turner, K-M. O'Sullivan, M. Dewerchin, H. R. Lijnen

Journal:

Journal of Thrombosis and Haemostasis

Year:

2003

Language:

english

File:

PDF, 261 KB

english, 2003

5

Gender-specific hypertension in mice deficient in the alpha1 subunit of soluble guanylate cyclase

Patrick Sips, Emmanuel Buys, Robrecht Thoonen, Anje Cauwels, Elke Rogge, Maureen Van Den Hemel, Mieke Dewerchin, Peter Brouckaert

Journal:

BMC Pharmacology

Year:

2005

Language:

english

File:

PDF, 240 KB

english, 2005

6

Lessons from soluble guanylate cyclase alpha1 knockouts

Peter Brouckaert, Emmanuel Buys, Patrick Sips, Robrecht Thoonen, Elke Rogge, Maureen Van Den Hemel, Mieke Dewerchin, Anje Cauwels

Journal:

BMC Pharmacology

Year:

2005

Language:

english

File:

PDF, 196 KB

english, 2005

7

Vasculaire endotheliale groeifactor en hypoxie-induceerbare factor 2α: drijvende krachten achter longmaturatie; belang voor respiratoir distress syndroom

V. Compernolle, M. Dewerchin, L. Moons, P. Carmeliet

Journal:

Tijdschrift voor Kindergeneeskunde

Year:

2005

File:

PDF, 152 KB

2005

8

Replication of feline coronaviruses in peripheral blood monocytes

H. L. Dewerchin, E. Cornelissen, H. J. Nauwynck

Journal:

Archives of Virology

Year:

2005

Language:

english

File:

PDF, 707 KB

english, 2005

9

The role of proteinases in angiogenesis, heart development, restenosis, atherosclerosis, myocardial ischemia, and stroke: Insights from genetic studies

Aernout Luttun, Mieke Dewerchin, Désiré Collen, Peter Carmeliet

Journal:

Current Atherosclerosis Reports

Year:

2000

Language:

english

File:

PDF, 432 KB

english, 2000

10

Targeted disruption of the murine Plag1 proto-oncogene causes growth retardation and reduced fertility

Karen Hensen, Caroline Braem, Jeroen Declercq, Frederik Van Dyck, Mieke Dewerchin, Laurence Fiette, Carl Denef, Wim J. M. Van de Ven

Journal:

Development, Growth & Differentiation

Year:

2004

Language:

english

File:

PDF, 1.00 MB

english, 2004

11

Inhibition of factor VIII with a partially inhibitory human recombinant monoclonal antibody prevents thrombotic events in a transgenic model of type II HBS antithrombin deficiency in mice

M. Dewerchin, L. Van Der Elst, I. Singh, S. Grailly, J-M. Saint-Remy, D. Collen, M. Jacquemin

Journal:

Journal of Thrombosis and Haemostasis

Year:

2004

Language:

english

File:

PDF, 176 KB

english, 2004

12

Variable region heavy chain glycosylation determines the anticoagulant activity of a factor VIII antibody

M. JACQUEMIN, C. M. RADCLIFFE, R. LAVEND'HOMME, M. R. WORMALD, L. VANDERELST, G. WALLAYS, J. DEWAELE, D. COLLEN, J. VERMYLEN, R. A. DWEK, J-M SAINT-REMY, P. M. RUDD, M. DEWERCHIN

Journal:

Journal of Thrombosis and Haemostasis

Year:

2006

Language:

english

File:

PDF, 400 KB

english, 2006

13

Functional genomics to study angiogenesis in health and disease

Mieke Dewerchin

Journal:

Experimental Dermatology

Year:

2007

Language:

english

File:

PDF, 49 KB

english, 2007

14

Insights in Vessel Development and Vascular Disorders Using Targeted Inactivation and Transfer of Vascular Endothelial Growth Factor, the Tissue Factor Receptor, and the Plasminogen System

PETER CARMELIET, LIEVE MOONS, M. DEWERCHIN, NIGEL MACKMAN, THOMAS LUTHER, GEORG BREIER, V. PLOPLIS, M. MÜLLER, A. NAGY, E. PLOW, R. GERARD, THOMAS EDGINGTON, W. RISAU, DÉSIRÉ COLLEN

Journal:

Annals of the New York Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 984 KB

english, 1997

15

10.1038/26791

Carmeliet, Peter, Dor, Yuval, Herbert, Jean-Marc, Fukumura, Dai, Brusselmans, Koen, Dewerchin, Mieke, Neeman, Michal, Bono, FranÇoise, Abramovitch, Rinat, Maxwell, Patrick, Koch, Cameron J., Ratcliffe

Journal:

Year:

1998

Language:

english

File:

PDF, 1.44 MB

english, 1998

16

10.1038/28867

Carmeliet, Peter, Dor, Yuval, Herbert, Jean-Marc, Fukumura, Dai, Brusselmans, Koen, Dewerchin, Mieke, Neeman, Michal, Bono, Françoise, Abramovitch, Rinat, Maxwell, Patrick, Koch#, Cameron J., Ratcliff

Journal:

Year:

1998

Language:

english

File:

PDF, 734 KB

english, 1998

17

10.1038/84667

Angelillo-Scherrer, Anne, de Frutos, Pablo Garcia, Aparicio, Cristina, Melis, Els, Savi, Pierre, Lupu, Florea, Arnout, Jef, Dewerchin, Mieke, Hoylaerts, Marc F., Herbert, Jean-Marc, Collen, Désiré, Da

Journal:

Nature Medicine

Year:

2001

Language:

english

File:

PDF, 1.35 MB

english, 2001

18

10.1038/88842

Oosthuyse, Bert, Moons, Lieve, Storkebaum, Erik, Beck, Heike, Nuyens, Dieter, Brusselmans, Koen, Dorpe, Jo Van, Hellings, Peter, Gorselink, Marchel, Heymans, Stéphane, Theilmeier, Gregor, Dewerchin, M

Journal:

Nature Genetics

Year:

2001

Language:

english

File:

PDF, 1.73 MB

english, 2001

19

10.1038/nm0901-1021

Nuyens, Dieter, Stengl, Milan, Dugarmaa, Saran, Rossenbacker, Tom, Compernolle, Veerle, Rudy, Yoram, Smits, Jos F., Flameng, Willem, Clancy, Colleen E., Moons, Lieve, Vos, Marc A., Dewerchin, Mieke, B

Journal:

Nature Medicine

Year:

2001

Language:

english

File:

PDF, 1.50 MB

english, 2001

20

Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

Compernolle, V., Brusselmans, K., Acker, T., Hoet, P., Tjwa, M., Beck, H., Plaisance, S., Dor, Y., Keshet, E., Lupu, F., Nemery, B., Dewerchin, M., Van Veldhoven, P., Plate, K., Moons, L., Collen, D.,

Journal:

Nature Medicine

Year:

2002

Language:

english

File:

PDF, 64 KB

english, 2002

21

Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

Compernolle, Veerle, Brusselmans, Koen, Acker, Till, Hoet, Peter, Tjwa, Marc, Beck, Heike, Plaisance, Stéphane, Dor, Yuval, Keshet, Eli, Lupu, Florea, Nemery, Benoit, Dewerchin, Mieke, Van Veldhoven,

Journal:

Nature Medicine

Year:

2002

Language:

english

File:

PDF, 1.54 MB

english, 2002

22

Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS

Storkebaum, Erik, Lambrechts, Diether, Dewerchin, Mieke, Moreno-Murciano, Maria-Paz, Appelmans, Saskia, Oh, Hideyasu, Van Damme, Philip, Rutten, Bart, Man, Wing Yan, De Mol, Maria

Journal:

Nature Neuroscience

Year:

2004

Language:

english

File:

PDF, 1001 KB

english, 2004

23

Adenovirus-mediated overexpression of human tissue plasminogen activator prevents peritoneal adhesion formation/reformation in rats

Hussein M. Atta, Ayman Al-Hendy, Mahmoud A. El-Rehany, Mieke Dewerchin, Salama R. Abdel Raheim, Hend Abdel Ghany, Rasha Fouad

Journal:

Year:

2009

Language:

english

File:

PDF, 168 KB

english, 2009

24

Absence of surface expression of feline infectious peritonitis virus (FIPV) antigens on infected cells isolated from cats with FIP

E. Cornelissen, H.L. Dewerchin, E. Van Hamme, H.J. Nauwynck

Journal:

Veterinary Microbiology

Year:

2007

Language:

english

File:

PDF, 219 KB

english, 2007

25

Fibrinolysis-independent role of plasmin and its activators in the haematopoietic recovery after myeloablation

Marc Tjwa, Rute Moura, Lieve Moons, Stephane Plaisance, Maria De Mol, Sandra Jansen, Mieke Dewerchin, Catherine Verfaillie, Peter Carmeliet

Journal:

Journal of Cellular and Molecular Medicine

Year:

2009

Language:

english

File:

PDF, 1.14 MB

english, 2009

26

Design of novel artemisinin-like derivatives with cytotoxic and anti-angiogenic properties

Shahid Soomro, Tobias Langenberg, Anne Mahringer, V. Badireenath Konkimalla, Cindy Horwedel, Pavlo Holenya, Almut Brand, Canan Cetin, Gert Fricker, Mieke Dewerchin, Peter Carmeliet, Edward M. Conway,

Journal:

Journal of Cellular and Molecular Medicine

Year:

2011

Language:

english

File:

PDF, 1.02 MB

english, 2011

27

Biochemical properties of conjugates of urokinase-type plasminogen activator with a monoclonal antibody specific for cross-linked fibrin

Maria DEWERCHIN, H. Roger LIJNEN, Berthe Van HOEF, Frans De COCK, Désiré COLLEN

Journal:

Year:

1989

Language:

english

File:

PDF, 939 KB

english, 1989

28

Characterization of a recombinant chimeric plasminogen activator composed of a fibrin fragment-d-dimer-specific humanized monoclonal antibody and a truncated single-chain urokinase

Anne-Mieke VANDAMME, Maria DEWERCHIN, H. Roger LIJNEN, Hilde BERNAR, Frank BULENS, Luc NELLES, Désiré COLLEN

Journal:

Year:

1992

Language:

english

File:

PDF, 871 KB

english, 1992

29

Targeted Deletion of the Cytosolic Domain of Tissue Factor in Mice Does Not Affect Development

Els Melis, Lieve Moons, Maria De Mol, Jean-Marc Herbert, Nigel Mackman, Désiré Collen, Peter Carmeliet, Mieke Dewerchin

Journal:

Biochemical and Biophysical Research Communications

Year:

2001

Language:

english

File:

PDF, 226 KB

english, 2001

30

Thrombophilia in mice expressing a tissue factor variant lacking its transmembrane and cytosolic domain

Els Melis, Lieve Moons, Jef Arnout, Marc F. Hoylaerts, Désiré Collen, Peter Carmeliet, Mieke Dewerchin

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 1.21 MB

english, 2005

31

Deficiency of vascular endothelial growth factor-D does not affect murine adipose tissue development

H.R. Lijnen, L. Frederix, B. Van Hoef, M. Dewerchin

Journal:

Biochemical and Biophysical Research Communications

Year:

2009

Language:

english

File:

PDF, 193 KB

english, 2009

32

Transcription factor COUP-TFII is indispensable for venous and lymphatic development in zebrafish and Xenopus laevis

Xabier L. Aranguren, Manu Beerens, Wouter Vandevelde, Mieke Dewerchin, Peter Carmeliet, Aernout Luttun

Journal:

Biochemical and Biophysical Research Communications

Year:

2011

Language:

english

File:

PDF, 987 KB

english, 2011

33

Loss of the PlagL2 Transcription Factor Affects Lacteal Uptake of Chylomicrons

Frederik Van Dyck, Caroline V. Braem, Zhao Chen, Jeroen Declercq, Rob Deckers, Byeong-Moo Kim, Susumu Ito, Michele K. Wu, David E. Cohen, Mieke Dewerchin, Rita Derua, Etienne Waelkens, Laurence Fiette

Journal:

Cell Metabolism

Year:

2007

Language:

english

File:

PDF, 1.42 MB

english, 2007

34

The role of different VEGF isoforms in scar formation after glaucoma filtration surgery

Tine Van Bergen, Evelien Vandewalle, Sara Van de Veire, Mieke Dewerchin, Jean-Marie Stassen, Lieve Moons, Ingeborg Stalmans

Journal:

Experimental Eye Research

Year:

2011

Language:

english

File:

PDF, 1.16 MB

english, 2011

35

Male fertility and protein C inhibitor/plasminogen activator inhibitor-3 (PCI): localization of PCI in mouse testis and failure of single plasminogen activator knockout to restore spermatogenesis in PCI-deficient mice

Pavel Uhrin, Christian Schöfer, Jan Zaujec, Lubos Ryban, Mario Hilpert, Klara Weipoltshammer, Ingrid Jerabek, Irene Pirtzkall, Margareta Furtmüller, Mieke Dewerchin, Bernd R. Binder, Margarethe Geiger

Journal:

Fertility and Sterility

Year:

2007

Language:

english

File:

PDF, 1.71 MB

english, 2007

36

33: Adenovirus-Mediated Overexpression of Human t-PA Prevents Peritoneal Adhesion Formation/Reformation in Rats

H.M. Atta, A. Al-Hendy, M.A. El-Rehany, S.R. Abdel Raheim, H.M. Abd Elghany, R. Foad, M. Dewerchin

Journal:

Journal of Surgical Research

Year:

2009

Language:

english

File:

PDF, 96 KB

english, 2009

37

O14. Functional knockout of the soluble guanylate cyclase alpha 1 subunit leads to gender-specific hypertension while retaining sensitivity to nitric oxide

Patrick Yves Sips, Emmanuel Buys, Elke Rogge, Sofie Nimmegeers, Mieke Dewerchin, Johan Van de Voorde, Peter Brouckaert

Journal:

Year:

2006

Language:

english

File:

PDF, 74 KB

english, 2006

38

In vitro assessment of the feline cell-mediated immune response against feline panleukopeniavirus, calicivirus and felid herpesvirus 1 using 5-bromo-2′-deoxyuridine labeling

Ben L. Vermeulen, Sabine E. Gleich, Annelike Dedeurwaerder, Dominique A. Olyslaegers, Lowiese M. Desmarets, Hannah L. Dewerchin, Hans J. Nauwynck

Journal:

Veterinary Immunology and Immunopathology

Year:

2012

Language:

english

File:

PDF, 601 KB

english, 2012

39

Absence of antibody-dependent, complement-mediated lysis of feline infectious peritonitis virus-infected cells

E. Cornelissen, H.L. Dewerchin, E. Van Hamme, H.J. Nauwynck

Journal:

Year:

2009

Language:

english

File:

PDF, 659 KB

english, 2009

40

Intriguing interplay between feline infectious peritonitis virus and its receptors during entry in primary feline monocytes

Evelien Van Hamme, Lowiese Desmarets, Hannah L. Dewerchin, Hans J. Nauwynck

Journal:

Year:

2011

Language:

english

File:

PDF, 411 KB

english, 2011

41

Effect of culture conditions on mycelial and yeast-like growth of Ceratocystis multiannulata

Mieke A. Dewerchin, André J. van Laere

Journal:

Transactions of the British Mycological Society

Year:

1985

Language:

english

File:

PDF, 300 KB

english, 1985

42

Targeted Deficiency or Cytosolic Truncation of the VE-cadherin Gene in Mice Impairs VEGF-Mediated Endothelial Survival and Angiogenesis

Peter Carmeliet, Maria-Grazia Lampugnani, Lieve Moons, Ferrucio Breviario, Veerle Compernolle, Françoise Bono, Giovanna Balconi, Raffaella Spagnuolo, Bert Oosthuyse, Mieke Dewerchin, Adriana Zanetti,

Journal:

Year:

1999

Language:

english

File:

PDF, 687 KB

english, 1999

43

78 Receptor-independent role of urokinase-type plasminogen activator during vascular wound healing in mice

P. Carmeliet, L. Moons, M. Dewerchin, S. Rosenberg, J.-M. Herbert, F. Lupu, D. Collen

Journal:

Fibrinolysis and Proteolysis

Year:

1997

Language:

english

File:

PDF, 109 KB

english, 1997

44

190 Characterization and targeting of the murine α2-antiplasmin gene

H.R. Lijnen, M. Dewerchin, K. Okada, A. Belayew, D. Collen

Journal:

Fibrinolysis and Proteolysis

Year:

1997

Language:

english

File:

PDF, 126 KB

english, 1997

45

Vascular and cellular proteolytic activity in mice with α2-antiplasmin gene inactivation

H.R. Lijnen, F. Ugwu, E. Maquoi, G. Lemmens, B.Van Hoef, M. Dewerchin, D. Collen

Journal:

Fibrinolysis and Proteolysis

Year:

2000

Language:

english

File:

PDF, 70 KB

english, 2000

46

Natural killer cells: Frequency, phenotype and function in healthy cats

Ben L. Vermeulen, Bert Devriendt, Dominique A. Olyslaegers, Annelike Dedeurwaerder, Lowiese M. Desmarets, Korneel L. Grauwet, Herman W. Favoreel, Hannah L. Dewerchin, Hans J. Nauwynck

Journal:

Veterinary Immunology and Immunopathology

Year:

2012

Language:

english

File:

PDF, 628 KB

english, 2012

47

Effect of fibrin-targeting on clot lysis with urokinase-type plasminogen activator

H.R. Lijnen, M. Dewerchin, F. De Cock, D. Collen

Journal:

Thrombosis Research

Year:

1990

Language:

english

File:

PDF, 774 KB

english, 1990

48

Inactivation of the mouse urokinase-receptor gene

M. Dewerchin, P. Carmeliet, A. Van Nuffelen, D. Collen, R.C. Mulligan

Journal:

Fibrinolysis and Proteolysis

Year:

1994

Language:

english

File:

PDF, 141 KB

english, 1994

49

Quantitative analysis of an anti-viral immune escape compound ML-7 in feline plasma using ultra performance liquid chromatography/electrospray ionization mass spectrometry

Marc Cherlet, Sabine Gleich, Hannah Dewerchin, Hans Nauwynck, Sylvie Daminet, Patrick De Backer, Siska Croubels

Journal:

Journal of Chromatography B

Year:

2012

Language:

english

File:

PDF, 815 KB

english, 2012

50

Role of vascular endothelial growth factor and placental growth factor in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice

Carlos Roger Molinas, Rudi Campo, Mieke Dewerchin, Ulf Eriksson, Peter Carmeliet, Philippe Robert Koninckx

Journal:

Fertility and Sterility

Year:

2003

Language:

english

File:

PDF, 132 KB

english, 2003

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